William Christoph of Hesse-Homburg (13 November 1625, Ober-Rosbach – 27 August 1681, then in Bingenheim, now in Echzell) was the second Landgraf of Hesse-Homburg (then known as "Landgraf of Bingenheim"). He was the third (second surviving) of five sons of Frederick I, Landgrave of Hesse-Homburg, and succeeded his brother Ludwig I as Landgrave in 1643.
In 1669, he sold Homburg to his younger brother George Christian, but retained Bingenheim (Landgrave of Hesse-Homburg-Bingenheim). George Christian died without heirs, and their youngest brother succeeded as Frederick II, Landgrave of Hesse-Homburg.
He married Sophia Eleonora, daughter of George II, Landgrave of Hesse-Darmstadt. George II was his first cousin, as both were grandsons of George I, Landgrave of Hesse-Darmstadt.
They had 12 children, but only three survived infancy:
On 2 April 1665 William Christoph married Anna Elisabeth of Saxe-Lauenburg (*23 August 1624 – 27 May 1688*) in Lübeck. She was a daughter of Duke Augustus of Saxe-Lauenburg. In 1672 they were divorced and Anna Elisabeth retired to and later died in Philippseck Castle in today's Butzbach.